Near-infrared Raman spectroscopy to study the composition of human brain tissue and tumors

Christoph Krafft; Snezana Miljanic; Stephan B. Sobottka; Gabriele Schackert M.D.; Reiner Salzer

doi:10.1117/12.500469

8 October 2003 Near-infrared Raman spectroscopy to study the composition of human brain tissue and tumors

Christoph Krafft, Snezana Miljanic, Stephan B. Sobottka, Gabriele Schackert M.D., Reiner Salzer

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500469
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

The composition of human brain tissue and brain tumors were studied by near infrared Raman spectroscopy with 785 nm excitation. The amounts of lipids, cholesterol, protein and water in fresh specimens were determined from Raman spectra by a combination of pure component spectra. Normal brain tissue was found to contain higher levels of lipids and cholesterol, brain tumors such as glioma and meningeoma displayed less lipids and cholesterol, but more proteins, in particular more hemoglobin-like molecules. These results demonstrate the applicability of Raman spectroscopy for real-time, in vivo, intraoperative diagnosis.

Citation Download Citation

Christoph Krafft, Snezana Miljanic, Stephan B. Sobottka, Gabriele Schackert M.D., and Reiner Salzer "Near-infrared Raman spectroscopy to study the composition of human brain tissue and tumors", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500469

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available