14 October 2003 Use of acousto-optic tunable filter in fluorescence imaging endoscopy
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A prototype instrument for fluorescence-based medical diagnostics in vivo is described. The system consists of a rigid endoscope comprising a UV laser-source for fluorescence excitation and a white light source for direct imaging. An acousto-optic tuneable filter (AOTF) is employed as a full-field tuneable bandpass filter. This allows fast continuous or random-access tuning with high filtering efficiency. A study of the diagnostic potential of fluorescence imaging for pancreatitis was conducted on a rat model. In particular, the aim was to detect autofluorescence of endogenous protoporphyrin IX (PpIX) that has been shown to accumulate in early-stage diseased tissue undergoing an inflammatory response.
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Mounir Bouhifd, Mounir Bouhifd, Maurice Whelan, Maurice Whelan, Marc Aprahamian, Marc Aprahamian, } "Use of acousto-optic tunable filter in fluorescence imaging endoscopy", Proc. SPIE 5143, Novel Optical Instrumentation for Biomedical Applications, (14 October 2003); doi: 10.1117/12.500700; https://doi.org/10.1117/12.500700

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