Cellular mechanisms of low-power laser therapy

Tiina I. Karu

doi:10.1117/12.518686

22 September 2003 Cellular mechanisms of low-power laser therapy

Tiina I. Karu

Proceedings Volume 5149, Laser Applications in Medicine, Biology, and Environmental Science; (2003) https://doi.org/10.1117/12.518686
Event: International Conference on Lasers, Applications, and Technologies 2002, 2002, Moscow, Russian Federation

Abstract

Cytochrome c oxidase is considered as the photoacceptor when eukaryotic cells are exposed to monochromatic red to near-IR radiation. Five primary mechanisms are discussed: changes in the redox properties of the respiratory chain components following photoexcitation of their electronic states, NO release from catalytic center of cytochrome c oxidase, generation of singlet oxygen, localized transient heating of absorbing chromophores, in creased superoxide anion production with a subsequent increase in the concentration of H₂O₂. A cascade of reactions related to the alteration of cellular homeostasis parameters (pH_i, [Ca_i], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).

Citation Download Citation

Tiina I. Karu "Cellular mechanisms of low-power laser therapy", Proc. SPIE 5149, Laser Applications in Medicine, Biology, and Environmental Science, (22 September 2003); https://doi.org/10.1117/12.518686

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