Small-animal radionuclide imaging with focusing gamma-ray optics

Michael J. Pivovaroff; William B. Barber; Finn Erland Christensen; William W. Craig; Todd Decker; Michael Epstein; Tobias Funk; Charles J. Hailey; Bruce H. Hasegawa; Randy Hill; Jesse G. Jernigan; C. Taylor; Klaus P. Ziock

doi:10.1117/12.511741

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30 December 2003 Small-animal radionuclide imaging with focusing gamma-ray optics

Michael J. Pivovaroff, William B. Barber, Finn Erland Christensen, William W. Craig, Todd Decker, Michael Epstein, Tobias Funk, Charles J. Hailey, Bruce H. Hasegawa, Randy Hill, Jesse G. Jernigan, C. Taylor, Klaus P. Ziock

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Proceedings Volume 5199, Penetrating Radiation Systems and Applications V; (2003) https://doi.org/10.1117/12.511741
Event: Optical Science and Technology, SPIE's 48th Annual Meeting, 2003, San Diego, California, United States

Abstract

Significant effort currently is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. While physiological function in small animals can be localized and imaged using conventional radionuclide imaging techniques such as single-photon emission tomography (SPECT) and positron emission tomography (PET), these techniques inherently are limited to spatial resolutions of 1-2 mm. For this reason, we are developing a small animal radionuclide imaging system (SARIS) using grazing incidence optics to focus gamma-rays emitted by ¹²⁵I and other radiopharmaceuticals. We have developed a prototype optic with sufficient accuracy and precision to focus the 27.5 keV photons from ¹²⁵I onto a high-resolution imaging detector. Experimental measurements from the prototype have demonstrated that the optic can focus X-rays from a microfocus X-ray tube to a spot having physical dimensions (approximately 1500 microns half-power diameter) consistent with those predicted by theory. Our theoretical and numerical analysis also indicate that an optic can be designed and build that ultimately can achieve 100 μm spatial resolution with sufficient efficiency to perform it in vivo single photon emission imaging studies in small animal.

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Michael J. Pivovaroff, William B. Barber, Finn Erland Christensen, William W. Craig, Todd Decker, Michael Epstein, Tobias Funk, Charles J. Hailey, Bruce H. Hasegawa, Randy Hill, Jesse G. Jernigan, C. Taylor, and Klaus P. Ziock "Small-animal radionuclide imaging with focusing gamma-ray optics", Proc. SPIE 5199, Penetrating Radiation Systems and Applications V, (30 December 2003); https://doi.org/10.1117/12.511741

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