The integration of telemedicine with medical micro sensor technology (Mobile Sensor Networks for Telemedicine applications -- MSNT) provides a promising approach to improve the quality of people's lives. This type of network can truly implement the goal of providing health-care services anytime and anywhere. Our research in this field generates the following outcomes that are reported in this paper: (1) We propose a mobile sensor network infrastructure to support the third-generation telemedicine applications; (2) An energy-efficient query resolution mechanism in large-scale mobile sensor networks is used for critical medical data collections; (3) To provide the guaranteed mobile QoS for arriving multimedia calls, a new multi-class call admission control mechanism is proposed which is based on dynamically forming a reservation pool for handoff requests. We used discrete-event-based simulation model using OPNET to verify our scheme. The simulation results show that our system can satisfy the adaptive QoS requirements in large-scale telemedicine sensor networks.