8 December 2003 Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager
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Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546193
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China
Abstract
In the previous study, we have proved that Pyro-2DG could be trapped and accumulated in the tumor. The fluorescent signal of Pyro-2DG has high correlation with the redox ratio. To further study the extrinsic probe Pyro-2DG, the characteristic of Pyro-2DG uptake by the liver tissue of rats and the distribution of Pyro-2DG in various tissues were detected using the Cryo-Imager. The result indicated that Pyro-2DG uptake by the liver resulted in the metabolic state shift towards an increased concentration of oxidized electron carriers and it completely recovered after 24hrs. Pyro-2DG with infusion injection could avoid the oxidized damage of the normal tissue induced by Pyro-2DG uptake. The distribution of Pyro-2DG in various normal tissues indicated that Pyro-2DG could be as a tumor special near infrared ray (NIR) probe besides the hepatic tumor and lymph system tumor.
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Zhihong Zhang, Zhihong Zhang, Dana Blessington, Dana Blessington, Gang Zheng, Gang Zheng, Qingming Luo, Qingming Luo, Britton Chance, Britton Chance, } "Fluorescent imaging the characteristic of Pyro-2DG uptake in the normal tissue using the Cryo-Imager", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); doi: 10.1117/12.546193; https://doi.org/10.1117/12.546193
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