8 March 2004 Investigating photonic nanostructures for reproducible characterization of bacterial spores
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Proceedings Volume 5269, Chemical and Biological Point Sensors for Homeland Defense; (2004) https://doi.org/10.1117/12.514207
Event: Optical Technologies for Industrial, Environmental, and Biological Sensing, 2003, Providence, RI, United States
Abstract
Raman spectroscopy has proven to be a plausible solution to the difficult challenge of on-site detection of biological threats. Adding to the challenge is the fact that many biological species, spores specifically, have relatively low scattering cross sections. The intrinsic need to detect these threats at low concentrations and in the presence of strong background signals necessitates the need for surface enhancement schemes. With an available technique to quickly identify bacterial spores, we hope to find spectral differences between target species in order to incorporate library technologies with the on-site sensor. We are investigating many of the reported substrate classes such as: Nano-sphere lithography (NSL), Film over nano-sphere (FONS), nano-shells, electrochemically roughened metals, and dispersed and immobilized colloids. The key aspects of this work include discerning what architectural features provide the largest enhancement and reproducibility. We will present preliminary results of bacterial spore identification as well as a comparison of the substrates studied.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jay E. Pendell Jones, Nick F. Fell, Troy Alexander, Christin Tombrello, Augustus W. Fountain, "Investigating photonic nanostructures for reproducible characterization of bacterial spores", Proc. SPIE 5269, Chemical and Biological Point Sensors for Homeland Defense, (8 March 2004); doi: 10.1117/12.514207; https://doi.org/10.1117/12.514207
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