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An optical fiber calcium ion sensor is developed through the exploitation of the natural selectivity of the Ca+2 binding
properties of the fluorescent probe Calcium Orange (Molecular Probes, Eugene, OR). A multi-mode optical fiber is used to detect calcium in solution. There is a two and a half fold increase observed between a 1 mM EGTA + buffer solution and a 1 mM Ca2+ solution. A variety of different methods of attaching the molecular probe to the end of the fiber are explored.
Monika Arora,Grace Doan,Sonia R. Anderson,Florence Nwachukwu, andThomas K. Plant
"Optical fiber calcium ion sensor: development and testing", Proc. SPIE 5278, Sixth Pacific Northwest Fiber Optic Sensor Workshop, (20 November 2003); https://doi.org/10.1117/12.544399
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Monika Arora, Grace Doan, Sonia R. Anderson, Florence Nwachukwu, Thomas K. Plant, "Optical fiber calcium ion sensor: development and testing," Proc. SPIE 5278, Sixth Pacific Northwest Fiber Optic Sensor Workshop, (20 November 2003); https://doi.org/10.1117/12.544399