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28 May 2004 LC vision application to malignant tumor detection
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The free thin nematic liquid crystal (NLC) layers applied on the surface and observed in polarizing microscope are being used in the science and high technologies for structural inhomogeneities detection on the surface of materials. Simplicity, efficiency and high sensitivity have given an opportunity of NLC application in cancer detection. There were three stages in our investigations. 1. It was discovered that on malignant tissues of animals and human beings NLC have homeotropic orientation while on benign tissues they have planar or tilted orientation. 2. The discovered phenomenon was explained by the surface tension value difference on malignant and benign tumors. 3. The difference in surface tension is based on the particularities of the different parts of the interface layer. The “water” on the boundary with malignant tissues has higher order parameter in comparison with benign tissue. The difference in order parameter was explained by higher concentration of the protein and less concentration of lipids in the “water” on malignant tissues. As the result the anchoring NLC energy on the surface of structural water is higher in comparison with benign tissue. In the first case the NLC have homeotropic orientation in the whole volume of NLC layer while in the second case the surface Fredericks transition is observed.
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Maxim Georg Tomilin, A. F. Kurmashev, and Sergey A. Povzun "LC vision application to malignant tumor detection", Proc. SPIE 5289, Liquid Crystal Materials, Devices, and Applications X and Projection Displays X, (28 May 2004);

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