Analysis of birefringent image in the retinal nerve fiber layer by polarization-sensitive optical coherence tomography

Jesung Park; Nate J. Kemp; Hatham N. Zaatari; Thomas E. Milner; H. Grady Rylander III

doi:10.1117/12.529607

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13 July 2004 Analysis of birefringent image in the retinal nerve fiber layer by polarization-sensitive optical coherence tomography

Jesung Park, Nate J. Kemp, Hatham N. Zaatari, Thomas E. Milner, H. Grady Rylander III

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Proceedings Volume 5314, Ophthalmic Technologies XIV; (2004) https://doi.org/10.1117/12.529607
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Phase retardation per unit depth (PR/UD) is a physiologically significant parameter which correlates with the orderly arrangement of neurons and neurofibrils within the retinal nerve fiber layer (RNFL) and can vary in glaucoma. The objective of this study is to use Polarization Sensitive Optical Coherence Tomography (PSOCT), to detect both RNFL thickness and depth-resolved birefringence and produce thickness and PR/UD maps of the primate RNFL. RNFL thickness is obtained from the PSOCT intensity image with boundary detection using imaging processing methods. Analysis of PR/UD begins with calculating the Stokes parameters from the horizontal magnitude, vertical magnitude and relative phase difference in the interference fringes of light back scattered from the retina. Computed Stokes parameters are used to determine the fast axis in the RNFL and local phase retardation. PR/UD is calculated by dividing local birefringence by the corresponding RNFL thickness. A three-dimensional map of PR/UD and RNFL thickness is constructed by combining registered B-scans. Three-dimensional maps of thickness and PR/UD from the primate RNFL show that PSOCT is can be used for detecting thickness and PR/UD of the peripapillary RNFL and a very effective modality to diagnose glaucoma.

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Jesung Park, Nate J. Kemp, Hatham N. Zaatari, Thomas E. Milner, and H. Grady Rylander III "Analysis of birefringent image in the retinal nerve fiber layer by polarization-sensitive optical coherence tomography", Proc. SPIE 5314, Ophthalmic Technologies XIV, (13 July 2004); https://doi.org/10.1117/12.529607

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