14 June 2004 Optical fibers for improved light delivery in photodynamic therapy and diagnosis
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Abstract
For most Photodynamic Therapy (PDT) applications a diffuse, broad and uniform source of irradiation is needed to obtain the most effective and consistent treatment. Since many treatments are within the patient's body, an effective compact fiber optic delivery system is needed for the activation of the photsensitizer drub at the site of the tissue to be treated. High Numerical Aperture (NA) optical fibers have benefits for PDT treatments but possibly even more so for PDT diagnostic applications These are summarized and new optical fibers with high and ultra high NAs are described. Properties of these fibers are presented as well as advantages they have over other fibers for delivering light in various PDT applications. Silica fibers with enhanced effective NAs approaching 0.6 are described.
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Bolesh J. Skutnik, Wolfgang Neuberger, Stefan Spaniol, "Optical fibers for improved light delivery in photodynamic therapy and diagnosis", Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); doi: 10.1117/12.529489; https://doi.org/10.1117/12.529489
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KEYWORDS
Photodynamic therapy

Optical fibers

Silica

Near infrared

Tissue optics

Sodium

Diffusers

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