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1 July 2004 Ultrahigh-speed spectral domain optical coherence tomography of the human retina
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Properties and applications of Spectral Domain OCT have recently been explored, demonstrating improved signal to noise ratios and the potential for high-speed acquisition. In this presentation, we demonstrate in-vivo measurements of a human retina using a Spectral Domain system with acquisition rates of 10,000, 20,000, and 30,000 A-lines per second and 580 μW incident on the eye. Images consisting of 1000 depth profiles and ranging in width from 4 to 12 mm were acquired. The dynamic ranges within an image at 104, 2x104, and 3x104 lps were 40 dB, 39 dB and 28 dB respectively. These values are comparable to that of time domain Optical Coherence tomography yet are achieved at acquisition rates over 50 times faster, demonstrating video-rate OCT imaging at up to 30 frames/sec with 1000 A-lines per image. This work is more thoroughly described in the following publications: 1) B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen,J. F. de Boer, "In vivo dynamic human retinal blood flow imaging using ultra-high speed spectral domain optical doppler tomography," Opt. Express 11, 3490-3497 (2003). 2) N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004). 3) N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney,J. F. de Boer, "In-vivo human retinal imaging by ultra high-speed spectral domain optical coherence tomography," Optics Letters 29, 480-482 (2004).
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Nader A. Nassif, Barry Cense, B. Hyle Park, Mark C. Pierce, Brett E. Bouma, Guillermo J. Tearney, and Johannes F. de Boer "Ultrahigh-speed spectral domain optical coherence tomography of the human retina", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004);

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