Laser cutting of human bone and tissue is one of the oldest and most widespread applications of biophotonics. Due to the unique absorption of different kinds of tissue, choosing an appropriate laser wavelength allows selective ablation of tissue. Consequently, a large variety of laser sources with different emission wavelengths have been successfully applied to an equally large variety of medical indications. However, only a limited set of successful tissue-interaction experiments have translated into standard minimally-invasive procedures. One of the main reasons for this discrepancy between medical research and clinical practice is the lack of a commercially viable, flexible, and easy-to-use fiber optic beam delivery systems for wavelengths longer than 2 μm. In this paper, we will show how OmniGuide fibers, a new type of photonic bandgap fibers, could solve this problem. Recent performance data will be presented for both straight and bent fibers, including losses and power capacity, for delivery of CO2 lasers. We will also highlight medical procedures where these fibers could find first applications.