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1 July 2004 Simulation of selective photothermal interaction with dye enhancement
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Abstract
The precise and selective destruction of tumor tissue through hyperthermia, when combined with immunoadjuvant applications, has shown promise in the treatment of cancer. The combination of an 805-nm laser and indocyanine green (ICG) has been shown to be highly effective in laboratory experiments in satisfying both the precision and selectivity requirements of such a procedure. A systematic study was conducted to further understand the interaction of the laser and the dye, using both Monte Carlo simulation and direct temperature measurement in gel phantom and chicken tissue. A phantom system, with a spherical, dye-enhanced target in the center, was constructed to simulate a tumor buried in deep tissue. The temperature increase in the target tissue under the irradiation of the 805-nm laser was significantly higher than the surrounding tissue. The same tumor-tissue configuration was also used in the theoretical simulation. The theoretical and experimental results for the temperature distributions and the treatment parameters can be used to provide the optimal thermal effect in cancer treatment.
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Vinson G. Liu, Jared J. Crochet, Evan C. Lemley, and Wei R. Chen "Simulation of selective photothermal interaction with dye enhancement", Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); https://doi.org/10.1117/12.530581
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