Pulsed-ultrasound tagging of light in living tissues

Aner Lev; E. Rubanov; Ami Pomerantz; Bruno Gad Sfez

doi:10.1117/12.524985

12 July 2004 Pulsed-ultrasound tagging of light in living tissues

Aner Lev, E. Rubanov, Ami Pomerantz, Bruno Gad Sfez

Proceedings Volume 5320, Photons Plus Ultrasound: Imaging and Sensing; (2004) https://doi.org/10.1117/12.524985
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Ultrasound can be used in order to locally modulate, or tag, light in a turbid medium. This tagging process is made possible due to the extreme sensitivity of laser speckle distribution to minute changes within the medium. This hybrid technique presents several advantages compared to all-optical tomographic techniques, in that the image resolution is fixed by the ultrasound focus diameter. To our best knowledge, only in vitro experiments have been performed, either on tissue-like phantoms or meat. However a strong difference exists between these sample and living tissues. In living tissues, different kind of liquids flow through the capillaries, strongly reducing the sspeckle autocorrelation time. We have performed experiments on both mice and humans, showing that the autocorrelation time is much shorter than what was previously thought. We show however that it is possible to obtain signal with acceptable signal to noise ratio down to a few cm depth. We will also discuss the origin and characteristics of the speckle noise.

Citation Download Citation

Aner Lev, E. Rubanov, Ami Pomerantz, and Bruno Gad Sfez "Pulsed-ultrasound tagging of light in living tissues", Proc. SPIE 5320, Photons Plus Ultrasound: Imaging and Sensing, (12 July 2004); https://doi.org/10.1117/12.524985

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