Kerr-gated picosecond Raman spectroscopy and Raman photon migration of equine bone tissue with 400-nm excitation

Michael D. Morris; Allen E. Goodship; Edward R. C. Draper; Pavel Matousek; Michael Towrie; Anthony W. Parker

doi:10.1117/12.531517

1 July 2004 Kerr-gated picosecond Raman spectroscopy and Raman photon migration of equine bone tissue with 400-nm excitation

Michael D. Morris, Allen E. Goodship, Edward R. C. Draper, Pavel Matousek, Michael Towrie, Anthony W. Parker

Author Affiliations +

Proceedings Volume 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies; (2004) https://doi.org/10.1117/12.531517
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We show that Raman spectroscopy with visible lasers, even in the deep blue is possible with time-gated Raman spectroscopy. A 4 picosec time gate allows efficient fluorescence rejection, up to 1000X, and provides almost background-free Raman spectra with low incident laser power. The technology enables spectroscopy with better than 10X higher scattering efficiency than is possible with the NIR (785 nm and 830 nm) lasers that are conventionally used. Raman photon migration is shown to allow depth penetration. We show for the first time that Kerr-gated Raman spectra of bone tissue with blue laser excitation enables both fluorescence rejection and depth penetration.

Citation Download Citation

Michael D. Morris, Allen E. Goodship, Edward R. C. Draper, Pavel Matousek, Michael Towrie, and Anthony W. Parker "Kerr-gated picosecond Raman spectroscopy and Raman photon migration of equine bone tissue with 400-nm excitation", Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); https://doi.org/10.1117/12.531517

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