Progress in diagnostic pattern recognition (DPR)

Joachim Moecks; Gerrit Kocherscheidt; W. Koehler; Wolfgang H. Petrich

doi:10.1117/12.529288

1 July 2004 Progress in diagnostic pattern recognition (DPR)

Joachim Moecks, Gerrit Kocherscheidt, W. Koehler, Wolfgang H. Petrich

Proceedings Volume 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies; (2004) https://doi.org/10.1117/12.529288
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

The identification and analysis of disease-specific signatures in mid-infrared spectra of serum forms the basis of a method called “Diagnostic Pattern Recognition (DPR)”. A conceivable usage of this method in clinical diagnostics requires that the method be applied in a convenient and robust manner. Thus, automation, room-temperature operation and reproducibility the prerequisite improvements toward routine application. We have investigated the performance two identical, semi-automated DPR systems. In contrast to previous measurements, which required MCT detectors, the use of a DLaTGS detector allowed the systems to be operated without the requirement of liquid nitrogen cooling. A series of measurements showed that automated pipetting improves the reproducibility significantly as compared to manual pipetting. For automated pipetting, the within-day variations are of minor importance. However, day-to-day variations may decrease the reproducibility in some spectral regions by more than a factor of two. Slight dependence of the reproducibility on the protein content of the serum samples has been observed.

Citation Download Citation

Joachim Moecks, Gerrit Kocherscheidt, W. Koehler, and Wolfgang H. Petrich "Progress in diagnostic pattern recognition (DPR)", Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); https://doi.org/10.1117/12.529288

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available