Translator Disclaimer
1 July 2004 Progress in diagnostic pattern recognition (DPR)
Author Affiliations +
Abstract
The identification and analysis of disease-specific signatures in mid-infrared spectra of serum forms the basis of a method called “Diagnostic Pattern Recognition (DPR)”. A conceivable usage of this method in clinical diagnostics requires that the method be applied in a convenient and robust manner. Thus, automation, room-temperature operation and reproducibility the prerequisite improvements toward routine application. We have investigated the performance two identical, semi-automated DPR systems. In contrast to previous measurements, which required MCT detectors, the use of a DLaTGS detector allowed the systems to be operated without the requirement of liquid nitrogen cooling. A series of measurements showed that automated pipetting improves the reproducibility significantly as compared to manual pipetting. For automated pipetting, the within-day variations are of minor importance. However, day-to-day variations may decrease the reproducibility in some spectral regions by more than a factor of two. Slight dependence of the reproducibility on the protein content of the serum samples has been observed.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Joachim Moecks, Gerrit Kocherscheidt, W. Koehler, and Wolfgang H. Petrich "Progress in diagnostic pattern recognition (DPR)", Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); https://doi.org/10.1117/12.529288
PROCEEDINGS
7 PAGES


SHARE
Advertisement
Advertisement
Back to Top