Detection of integrins using surface-enhanced Raman spectroscopy

V. Alexander Gant; Mustafa Habib Chowdury; Gerald A. Meininger; Gerard L. Cote

doi:10.1117/12.535344

18 June 2004 Detection of integrins using surface-enhanced Raman spectroscopy

V. Alexander Gant; Mustafa Habib Chowdury; Gerald A. Meininger; Gerard L. Cote

Author Affiliations +

Proceedings Volume 5325, Optical Diagnostics and Sensing IV; (2004) https://doi.org/10.1117/12.535344
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Integrins play an important role in the adhesion of cells to extracellular matrix and to other cells around them, more specifically fibronectin. The ultimate goal of this research is to detect these integrins on the surface of the cell with a combined atomic force microscopy (AFM) system coupled with a surface enhanced Raman spectroscopy (SERS) system. For this paper the focus was on identifying whether SERS is capable of being used to generate a unique spectrum for integrins. This was done using silver colloidal particles and the integrins a5B1 and aVB3. It was shown that a unique spectrum could be identified for each of these integrins at the nanomolar level.

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V. Alexander Gant, V. Alexander Gant, Mustafa Habib Chowdury, Mustafa Habib Chowdury, Gerald A. Meininger, Gerald A. Meininger, Gerard L. Cote, Gerard L. Cote, } "Detection of integrins using surface-enhanced Raman spectroscopy", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); doi: 10.1117/12.535344; https://doi.org/10.1117/12.535344

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