18 June 2004 Glucose sensing in aqueous Intralipid suspension with an optical coherence tomography system: experiment and Monte Carlo simulation
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Abstract
Peculiarities of light transport in IntralipidTM solutions and the effect of glucose on light scattering properties of the solution at two different IntralipidTM concentrations were studied with optical coherence tomography (OCT) technique in vitro. An open air OCT system using a superluminescent light source with center wavelength = 830 nm was used. 5% IntralipidTM solutions were used to simulate a biological tissue (skin) in our experiment. Glucose concentrations at the physiologically relevant level were added to IntralipidTM solutions. Increasing IntralipidTM concentration increases the scattering coefficient of the media meanwhile increasing glucose concentration increases the refractive index of the media and reduces the scattering coefficient of the media. The experimental data were compared to Monte Carlo simulations. We also made the simulations for 2% IntralipidTM solution. The results indicate that glucose added to 2 and 5% IntralipidTM solutions changes their scattering properties, which is manifested by a decrease in the slope of the OCT signal. This finding shows the ways of using OCT for sensing glucose and monitoring the alterations of its content in biotissues. Some discrepancies between measurements and simulations were found, which need further investigation.
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Mikhail Yu. Kirillin, Mikhail Yu. Kirillin, Alexander V. Priezzhev, Alexander V. Priezzhev, Matti Kinnunen, Matti Kinnunen, Erkki Alarousu, Erkki Alarousu, Zuomin Zhao, Zuomin Zhao, Jukka T. Hast, Jukka T. Hast, Risto A. Myllylä, Risto A. Myllylä, } "Glucose sensing in aqueous Intralipid suspension with an optical coherence tomography system: experiment and Monte Carlo simulation", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); doi: 10.1117/12.535341; https://doi.org/10.1117/12.535341
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