Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection

Fei Yan; Musundi B. Wabuyele; Guy D. Griffin; Tuan Vo-Dinh

doi:10.1117/12.542455

16 June 2004 Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection

Fei Yan, Musundi B. Wabuyele, Guy D. Griffin, Tuan Vo-Dinh

Proceedings Volume 5327, Plasmonics in Biology and Medicine; (2004) https://doi.org/10.1117/12.542455
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We present the fabrication and characterization of silver island films with SiO₂ coatings for application in plasmonic sensors based on surface-enhanced fluorescence and Raman detection. The emission spectral properties of goat anti-mouse immunoglobulin (IgG) F(ab')₂labeled with one or two fluorescein residues were examined on substrates with metallic silver islands. The self-quenching of fluorescein emission was mostly eliminated when this antibody fragment was held 60-90 Å from the surface of metallic silver islands, and our preliminary experiments demonstrated an 8-fold emission intensity increase. Similar surfaces were also examined for surface-enhanced Raman analysis of Rhodamine 123, a potential drug for photodynamic therapy.

Citation Download Citation

Fei Yan, Musundi B. Wabuyele, Guy D. Griffin, and Tuan Vo-Dinh "Metallic nanostructures for plasmonic sensors using surface-enhanced fluorescence and Raman detection", Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); https://doi.org/10.1117/12.542455

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