22 June 2004 Demonstration of optical microfluidics
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We demonstrate a novel method for the control of small droplets using laser-based heating. Temperature dependent interfacial surface tensions were the primary force used to move droplets. With this approach, ~1.7 μL to 14 pL droplets were moved on a bare, unmodified polystyrene surface, at speeds of up to 3 mm/s. Upon contact, droplets spontaneously fused and rapidly mixed within 33 ms. We performed an optical absorption-based protein assay using horseradish peroxidase and a chromogenic substrate (ABTS), and readily detected as little as ~125 attomoles of reacting enzyme.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kenneth T. Kotz, Kenneth T. Kotz, Konstantinos S. Kalogerakis, Konstantinos S. Kalogerakis, Kyle A. Noble, Kyle A. Noble, Sarah E. Smith, Sarah E. Smith, Gregory W. Faris, Gregory W. Faris, } "Demonstration of optical microfluidics", Proc. SPIE 5328, Microarrays and Combinatorial Techniques: Design, Fabrication, and Analysis II, (22 June 2004); doi: 10.1117/12.538890; https://doi.org/10.1117/12.538890


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