14 June 2004 Novel near-infrared nanoparticlulate biomarker: preparation and stability studies
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Abstract
Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.
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Vishal Saxena, Vishal Saxena, Mostafa Sadoqi, Mostafa Sadoqi, Sunil Kumar, Sunil Kumar, Jun Shao, Jun Shao, } "Novel near-infrared nanoparticlulate biomarker: preparation and stability studies", Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); doi: 10.1117/12.534317; https://doi.org/10.1117/12.534317
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