28 May 2004 Nonlinear cellular dynamics of keratinocytes in normal and psoriatic epidermis under action of UV radiation
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Abstract
The semi-phenomenological model of epidermal cell dynamics is submitted. The model takes into account three types of basal layer keratinocytes (stem, transient amplifying, terminally differentiated), distribution of first two types cells on mitotic cycle stages and resting states, keratinocytes-lymphocytes interactions that provide a positive feedback loop, influence of more differentiated cells on their progenitors that provide a negative feedback loop. Simplified model are developed and its stationary solutions are received. The opportunity of interpretation of some received modes as corresponding to various stages of psoriasis is discussed. Influence of UV-radiation on transitions between various modes of epidermis functioning is qualitatively analyzed.
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Mikhail M. Stolnitz, Mikhail M. Stolnitz, Boris A. Medvedev, Boris A. Medvedev, Tatyana V. Gribko, Tatyana V. Gribko, } "Nonlinear cellular dynamics of keratinocytes in normal and psoriatic epidermis under action of UV radiation", Proc. SPIE 5330, Complex Dynamics, Fluctuations, Chaos, and Fractals in Biomedical Photonics, (28 May 2004); doi: 10.1117/12.530275; https://doi.org/10.1117/12.530275
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