23 December 2003 Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate
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Proceedings Volume 5345, Microfluidics, BioMEMS, and Medical Microsystems II; (2003) https://doi.org/10.1117/12.530062
Event: Micromachining and Microfabrication, 2004, San Jose, California, United States
Abstract
This paper describes the design and fabrication of an integrated optical glucose sensing system using the combination of the oxygen sensitive dye tris(2,2’-bipyridyl) dichlororuthenium(II) hexahydrate and glucose oxidase. Layer-by-layer self-assembly is used to immobilize the dye/enzyme system onto the surface of the waveguides. Changes in the enzyme/dye system as it interacts with the surrounding environment are monitored using end-face interaction with light injected into waveguides. The waveguides are thermally-defined monolithic polydimethlysiloxane (PDMS) waveguide system, fabricated on a PDMS substrate. The method of waveguide fabrication is a radical departure from conventional microscale waveguide systems, and offers unique opportunities for integration of this sensor into existing microfluidic systems.
© (2003) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
David A. Chang-Yen, David A. Chang-Yen, Bruce K. Gale, Bruce K. Gale, } "Integrated optical glucose sensor fabricated using PDMS waveguides on a PDMS substrate", Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); doi: 10.1117/12.530062; https://doi.org/10.1117/12.530062
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