23 December 2003 Simulation and design of micromixers for microfluidic devices
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Proceedings Volume 5345, Microfluidics, BioMEMS, and Medical Microsystems II; (2003) https://doi.org/10.1117/12.530788
Event: Micromachining and Microfabrication, 2004, San Jose, California, United States
Abstract
Passive (diffusional) mixing has been used in designing high-aspect-ratio micro-mixers for the purpose of performing Liagase Detection Reaction (LDR). The types of mixers considered are simple, cheap, and durable and can perform over a broad range of volumetric flow rates at reasonably modest pressure drops. The fluids to be mixed have a very low typical diffusion coefficient of=1.2x10-10m2/s and diffusional mixing is only effective in high-aspect-ratio micro-channels. A very modestly high aspect ratio of 6 has been considered initially because it is easily releasable using the LIGA technique. Numerical simulations of a few basic diffusional mixer configurations are going to be presented in this paper. Two variants of a Y-type mixer with contraction and several variants of a mixer employing jets in cross-flow have been simulated. The various mixers have been evaluated in terms of volumetric mixing efficiencies and maximum pressure drops. One of the mixers with jets-in-cross-flow was found to perform best.
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Amit Maha, Dwhyte O. Barrett, Dimitris E. Nikitopoulos, Steven A. Soper, Michael C. Murphy, "Simulation and design of micromixers for microfluidic devices", Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); doi: 10.1117/12.530788; https://doi.org/10.1117/12.530788
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