6 May 2004 Novel integrated bio-optical system for oxygen saturation measurement
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Abstract
The time resolved/time gated method can be used as a non-invasive technique for measuring changes in the concentration of oxy-and deoxy-hemoglobin in tissues by monitoring absorbed near infrared (NIR) signals in diffusion-reflectance and trans-illuminescence geometries. The objective is to develop novel technology that would enhance the efficiency of sensing in intact organism, in vivo, offering new capabilities for studying biological function by multispectral spectroscopy [1-4]. In this paper, we describe a novel scheme of an excitation source that enhances the spatial resolution and signal to noise ratio of detected NIR absorbed signals in diffusion reflectance spectroscopy technique used for measuring changes in the concentration of oxy-and deoxy-hemoglobin in tissues. We identify the properties and application of long visible and IR wavelength Vertical Cavity Surface Emitting Laser as an alternative 'Excitation Source'. We also investigate the Jitter performance of VCSELs in a high rate transmission systems like; the time gated reflectance absorbance spectroscopy system, as timing jitter of excitation source seriously degrades the temporal resolution of the collected absorbed luminescence at the detector end, which significantly effects the proper monitoring of the changes in the concentration of oxy- and deoxy-hemoglobin within the tissue.
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Vishal Saxena, Vishal Saxena, Jon Nielsen, Jon Nielsen, } "Novel integrated bio-optical system for oxygen saturation measurement", Proc. SPIE 5368, Medical Imaging 2004: Physics of Medical Imaging, (6 May 2004); doi: 10.1117/12.528651; https://doi.org/10.1117/12.528651
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