Methodology for quantifying and visualizing cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Hans Jorgen Gundersen; Soren Baarsgaard Hansen; Albert Gjedde; Hans Stodkilde-Jorgensen; Jorgen Marqversen; Ralf Agger; Tom E. Andersen; Charlotte C. Fleischer; Mikkel Steen Petersen; Marianne E. Hokland; Egil F. Hulgaard; Jan Trost Jorgensen; Ulrik Skands

doi:10.1117/12.535206

30 April 2004 Methodology for quantifying and visualizing cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging

Hans Jorgen Gundersen, Soren Baarsgaard Hansen, Albert Gjedde, Hans Stodkilde-Jorgensen, Jorgen Marqversen, Ralf Agger, Tom E. Andersen, Charlotte C. Fleischer, Mikkel Steen Petersen, Marianne E. Hokland, Egil F. Hulgaard, Jan Trost Jorgensen, Ulrik Skands

Author Affiliations +

Proceedings Volume 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images; (2004) https://doi.org/10.1117/12.535206
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

A method for precise and sensitive organ specific quantification of ¹²⁴I (¹²⁴IdUR) activities in small animals has been developed. The method is based upon high precision co-registration between PET and MR imagery, utilizing an innovative mouse fixation system with external point sources visible in both modalities. The methodology is generic, and thus can easily be extended to other types of small animal studies. The methodology comprises PET/MR rigid co-registration utilising external fiducial markers, measurement of activities within small 3D volumes manually drawn in MR data and extracted from the co-aligned PET data, and subsequently corrected for Partial Volume Effect.

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Hans Jorgen Gundersen, Soren Baarsgaard Hansen, Albert Gjedde, Hans Stodkilde-Jorgensen, Jorgen Marqversen, Ralf Agger, Tom E. Andersen, Charlotte C. Fleischer, Mikkel Steen Petersen, Marianne E. Hokland, Egil F. Hulgaard, Jan Trost Jorgensen, and Ulrik Skands "Methodology for quantifying and visualizing cell homing/accumulation by combined positron emission tomography and magnetic resonance imaging", Proc. SPIE 5369, Medical Imaging 2004: Physiology, Function, and Structure from Medical Images, (30 April 2004); https://doi.org/10.1117/12.535206

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