Corpus callosum analysis using MDL-based sequential models of shape and appearance

Mikkel B. Stegmann; Rhodri H. Davies; Charlotte Ryberg

doi:10.1117/12.535656

12 May 2004 Corpus callosum analysis using MDL-based sequential models of shape and appearance

Mikkel B. Stegmann, Rhodri H. Davies, Charlotte Ryberg

Proceedings Volume 5370, Medical Imaging 2004: Image Processing; (2004) https://doi.org/10.1117/12.535656
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

This paper describes a method for automatically analysing and segmenting the corpus callosum from magnetic resonance images of the brain based on the widely used Active Appearance Models (AAMs) by Cootes et al. Extensions of the original method, which are designed to improve this specific case are proposed, but all remain applicable to other domain problems. The well-known multi-resolution AAM optimisation is extended to include sequential relaxations on texture resolution, model coverage and model parameter constraints. Fully unsupervised analysis is obtained by exploiting model parameter convergence limits and a maximum likelihood estimate of shape and pose. Further, the important problem of modelling object neighbourhood is addressed. Finally, we describe how correspondence across images is achieved by selecting the minimum description length (MDL) landmarks from a set of training boundaries using the recently proposed method of Davies et al. This MDL-approach ensures a unique parameterisation of corpus callosum contour variation, which is crucial for neurological studies that compare reference areas such as rostrum, splenium, et cetera. We present quantitative and qualitative results that show that the method produces accurate, robust and rapid segmentations in a cross sectional study of 17 subjects, establishing its feasibility as a fully automated clinical tool for analysis and segmentation.

Citation Download Citation

Mikkel B. Stegmann, Rhodri H. Davies, and Charlotte Ryberg "Corpus callosum analysis using MDL-based sequential models of shape and appearance", Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); https://doi.org/10.1117/12.535656

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