White matter tractography based on minimizing the tracking cost model from diffusion tensor MRI

Wu Li; Jie Tian; Jianping Dai

doi:10.1117/12.535844

12 May 2004 White matter tractography based on minimizing the tracking cost model from diffusion tensor MRI

Wu Li, Jie Tian, Jianping Dai

Proceedings Volume 5370, Medical Imaging 2004: Image Processing; (2004) https://doi.org/10.1117/12.535844
Event: Medical Imaging 2004, 2004, San Diego, California, United States

Abstract

Diffusion tensor magnetic resonance imaging (DT-MRI) provides information about fiber direction in brain white matter and can be used for neuronal fiber pathways tracking. The purpose of our study is to develop and evaluate a novel approach for tracing anatomical fibers in vivo human brain from 3D DT-MRI tensor fields. The scheme is divided into two steps: regularization of tensor fields and fiber tracking. Firstly, 3D tensor fields are regularized to preserve directional information and discontinuous features, while removing uncorrelated noise from the data. Secondly, initiated from an operator-selected region, the anatomical fibers are bidirectionally traced based on minimizing the tracking cost (MTC) model. The model computes the possible direction of tract propagation, allowing a global trade-off among the entire tensor data, a prior knowledge of low curvature, and tracking inertia, instead of just the major eigenvector. Analysis on simulated data showed that the proposed method is less sensitive to image noise and partial volume effect than tracking using the major eigenvector, and overcomes the problem of fiber crossing successfully. Various estimated tracts obtained from human brain DT-MRI data showed that the proposed approach improves the reliability and robustness of fiber tractography. The proposed approach is effective and reproducible, which is promising for mapping the organizational patterns of white matter in the human brain as well as mapping the relationship between major fiber trajectories and the location and extent of brain lesions.

Citation Download Citation

Wu Li, Jie Tian, and Jianping Dai "White matter tractography based on minimizing the tracking cost model from diffusion tensor MRI", Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); https://doi.org/10.1117/12.535844

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KEYWORDS

Diffusion

Brain

Data modeling

3D modeling

Magnetic resonance imaging

Anisotropy

Brain mapping

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