This paper is devoted to numerical investigation of the influence of atmospheric processes, generated above a city, of transport of aerosol and gaseous compounds, emitted by industrial sources and urban vehicles. A numerical analysis is performed on the basis of a three-dimensional prognostic mesoscale model of the planetary boundary layer, which allows making predictions in the nested domains with a subsequent application of the turbulent diffusion model in order to simulate pollution dispersion and deposition of small compounds of the atmosphere above the surface with complex roughness and relief. Results of numerical experiment, carried out with the use of multiprocessor computers, reveal particularly to investigate generality of the near surface wind dynamics for representative adverse weather conditions, to understand the measure of its dependence on the surface factors, to determine the most adverse vortex structures, generation of which together with thermal stratification brings about accumulation of admixtures in the surface layer. Predictions confirm a close connection between urban meteorology and air quality in a city and its suburban area. Undesirable meteorological conditions for the majority of cities are temperature inversion and calm wind which transports "passed" pollution in urban air again.