16 August 2004 Micro-electro-mechanical systems (MEMS) for enzymatic detection
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Abstract
Early enzymatic identification and confirmation is essential for diagnosis and prevention as in the case of Acute Myocardial Infarction (AMI). Biochemical markers continue to be an important clinical tool for the enzymatic detection. The advent of MEMS devices can enable the use of various microstructures for the detection of enzymes. In this study, the concept of MEMS is applied for the detection of enzyme reaction, in which microcantilevers undergo changes in mechanical behavior that can be optically detected when enzyme molecules adsorb on their surface. This paper presents the static behavior of microcantilevers under Horse Radish Peroxide (HRP) enzyme reaction. The reported experimental results provide valuable information that will be useful in the development of MEMS sensors for enzymatic detection. The surface stress produced due to enzyme reactions results in the bending of cantilevers as similar to the influencing of thermal stress in the cantilevers. This paper also reports the influence of thermal gradient on the microcantilevers.
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Amritsar Jeetender, Amritsar Jeetender, Muthukumaran Packirisamy, Muthukumaran Packirisamy, Ion G. Stiharu, Ion G. Stiharu, Ganesharam Balagopal, Ganesharam Balagopal, "Micro-electro-mechanical systems (MEMS) for enzymatic detection", Proc. SPIE 5455, MEMS, MOEMS, and Micromachining, (16 August 2004); doi: 10.1117/12.547545; https://doi.org/10.1117/12.547545
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