20 August 2004 Influence of low-level laser irradiation to phagocytosis activity and proinflammation cytokins production
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Abstract
In this work was studied the influence of low-level laser irradiation (LLLI) generating semiconductor devices in red (650 nm) and infrared (850 nm) ranges of wavelength, in condition in vitro and in vivo on phagocytosis activity and synthesis by peritoneal macrophages endogenic proinflammatory cytokins at phagocytosis bacterial cells. In the power of phagocytosis stage was used the culture of clinical strains of enteropathogenic Escherichia coli. The variation of dose rendering influence accomplished with the help of variation power and an exposition of irradiation. Receiving results are evidence of stimulating activity infrared LLLI on phagocytosis activity of macrophages. We revealed the intensification of adhesion bacteria by macrophages, the intensification of bacteria's killing, and increase of production proinflammatory cytokins. Moreover we described effective revealed dose-dependent character. Influence of rays a red region of spectrum on phagocytosis macrophages caused some reduction of their activity increasing radiation dose was marked the destruction of the most macrophages.
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Dmitry V. Rudik, Elena I. Tikhomirova, Irina O. Bugaeva, "Influence of low-level laser irradiation to phagocytosis activity and proinflammation cytokins production", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.579166; https://doi.org/10.1117/12.579166
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