Optical investigations of metronidazolum action on the cell membranes and proteins

Era B. Popyhova; Pavel E. Kuznetsov; Svetlana M. Rogacheva; Konstantin I. Evlakov; Sergey A. Tolmachev; Machammad S. Kupadze

doi:10.1117/12.579162

20 August 2004 Optical investigations of metronidazolum action on the cell membranes and proteins

Era B. Popyhova, Pavel E. Kuznetsov, Svetlana M. Rogacheva, Konstantin I. Evlakov, Sergey A. Tolmachev, Machammad S. Kupadze

Author Affiliations +

Proceedings Volume 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V; (2004) https://doi.org/10.1117/12.579162
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation

Abstract

Photometric and fluorescence methods have been used for investigation of the drug 1-(2'hydroxiethil)-2-methil-5nitroimidazole (metronidazolum) action on the stability of erythrocytes and liposomes and on the protein folding. Metronidazolum was shown to protectively act on the cell membranes. Besides the compound was able to decrease the folding rate of the protein catalase. The molecular mechanism of the compound effect on the cell membranes and proteins was supposed to be modification of the hydrogen bonds net of the surface water. The last was proved by the results of molecular dynamics computation of parameters of hydrogen bonds net and clusters of water molecules in metronidazolum solution and in the solutions of inactive compounds.

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Era B. Popyhova, Pavel E. Kuznetsov, Svetlana M. Rogacheva, Konstantin I. Evlakov, Sergey A. Tolmachev, and Machammad S. Kupadze "Optical investigations of metronidazolum action on the cell membranes and proteins", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.579162

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