20 August 2004 Parallel fluorescence correlation spectroscopy with a fully integrated single photon 2x2 detector array made with conventional CMOS technology
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Proceedings Volume 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V; (2004); doi: 10.1117/12.578934
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation
Abstract
We present multipoint Fluorescence Correlation Spectroscopy (FCS) experiments with a fully integrated Complementary Metal Oxide Semiconductor (CMOS) single photon 2x2 detector array. Multifocal excitation was achieved with a diffractive optical element (DOE). Special emphasis was put on parallelization of the total system. In particular the performance of the single-photon CMOS detector was investigated and compared to a state-of-the art single-photon detecting module (actively quenched avalanche photo diode) by measurements on free diffusing molecules at different concentrations. The potential of our new technique for high throughput FCS based systems is discussed.
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Alexandre Serov, Michael Goesch, Alexis Rochas, Hans Blom, Tiemo Anhut, Pierre-Andre Besse, Radivoje S. Popovic, Theo Lasser, Rudolf Rigler, "Parallel fluorescence correlation spectroscopy with a fully integrated single photon 2x2 detector array made with conventional CMOS technology", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578934; https://doi.org/10.1117/12.578934
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KEYWORDS
Fluorescence correlation spectroscopy

Sensors

Molecules

CMOS sensors

Single photon

Diffusion

Diffractive optical elements

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