20 August 2004 Parallel fluorescence correlation spectroscopy with a fully integrated single photon 2x2 detector array made with conventional CMOS technology
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Abstract
We present multipoint Fluorescence Correlation Spectroscopy (FCS) experiments with a fully integrated Complementary Metal Oxide Semiconductor (CMOS) single photon 2x2 detector array. Multifocal excitation was achieved with a diffractive optical element (DOE). Special emphasis was put on parallelization of the total system. In particular the performance of the single-photon CMOS detector was investigated and compared to a state-of-the art single-photon detecting module (actively quenched avalanche photo diode) by measurements on free diffusing molecules at different concentrations. The potential of our new technique for high throughput FCS based systems is discussed.
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Alexandre Serov, Alexandre Serov, Michael Goesch, Michael Goesch, Alexis Rochas, Alexis Rochas, Hans Blom, Hans Blom, Tiemo Anhut, Tiemo Anhut, Pierre-Andre Besse, Pierre-Andre Besse, Radivoje S. Popovic, Radivoje S. Popovic, Theo Lasser, Theo Lasser, Rudolf Rigler, Rudolf Rigler, } "Parallel fluorescence correlation spectroscopy with a fully integrated single photon 2x2 detector array made with conventional CMOS technology", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.578934; https://doi.org/10.1117/12.578934
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