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7 July 2004 Factor analysis of excitation fluorescence spectra of camptothecin and its analogue: DB-67
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Proceedings Volume 5505, Optical Methods, Sensors, Image Processing, and Visualization in Medicine; (2004) https://doi.org/10.1117/12.577611
Event: Optical Methods, Sensors, Image Processing, and Visualization in Medicine, 2003, Gdansk, Poland
Abstract
The fluorescence excitation spectra of camptothecins -- alkaloids which have anticancer properties, are analyzed in this paper. Camptothecins exist in two forms -- biologically active lactone form and inactive carboxylate form. In fluids of pH 7,4 lactone forms hydrolyze and convert into carboxylate forms. There are some differences in shapes between fluorescence excitation spectra of lactone and carboxylate forms. One can observe evolution of fluorescence spectra during hydrolysis of camptothecins. Using principal component analysis and factor analysis to the set of fluorescence spectra recorded during process of hydrolysis of camptothecins one can determine the temporary concentration of lactone and carboxylate forms in solutions of pH 7,4 and obtain kinetics of deactivation of this compounds.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Stefan Kruszewski, Blanka Ziomkowska, Ryszard Siuda, and Michal Cyrankiewicz "Factor analysis of excitation fluorescence spectra of camptothecin and its analogue: DB-67", Proc. SPIE 5505, Optical Methods, Sensors, Image Processing, and Visualization in Medicine, (7 July 2004); https://doi.org/10.1117/12.577611
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