26 October 2004 A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner
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To show the feasibility of a combined micro-CT and micro-SPECT scanner based on use of polycapillary optics we inserted an optic between the radio-labeled specimen and our micro-CT scanner's imaging system. The micro-CT x-ray focal spot was placed at the focal point of the optic so that x-ray micro-CT of the specimen could also be performed without having to move the specimen. Using this set-up we scanned a 2 cm diameter Plexiglas cylinder with three (177 μCi) prostate brachytherapy seeds embedded in it. Each seed was 0.5 mm diameter, 4 mm long and filled with 0.4 mm diameter ceramic beads coated with 125Iodine. The SPECT images clearly resolve the layer of 125Iodine on the beads. That the SPECT image is spatially correct was cofirmed by the concurrent CT image. We also used a parallel polycapillary optic to scan a 1.5 cm Plexiglas cylinder with holes (2, 1, and 0.5 mm diameter, parallel to the cylinder axis) filled with a solution containing 11.56μCi/mm3 of 125Iodine. These data indicate a spatial resolution of 5 line pairs per mm at 10% modulation. Based on these results we propose a design that is more efficient at acquiring the scintigraphic image data.
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Steven M. Jorgensen, Steven M. Jorgensen, Michael S. Chmelik, Michael S. Chmelik, Diane R. Eaker, Diane R. Eaker, Carolyn A. MacDonald, Carolyn A. MacDonald, Erik Leo Ritman, Erik Leo Ritman, } "A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.560991; https://doi.org/10.1117/12.560991

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