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26 October 2004 Beam hardening correction and quantitative micro-CT
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The main use of micro-CT is to analyze bone structure, and values of the linear attenuation coefficients μ at every voxel position in the scanned volume are only used for the analysis of bone structure by establishing a threshold that separates bone from non-bone material. To additionally quantify the degree of mineralization of bone (DMB) from μ in multi-component samples, we corrected for beam hardening and its associated errors in DMB quantification caused by the polychromatic spectra of X-ray tubes used in bench-top micro-CT devices. The correction was implemented by simulating the difference of mono-chromatic and poly-chromatic X-ray sources and adding these differences to the original image in an iterative fashion. When applied to simple cylinders containing a single material, improvement on the constancy of the reconstructed voxel values could be observed to over 90% accuracy.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sven Prevrhal "Beam hardening correction and quantitative micro-CT", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004);

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