26 August 2004 Analysis of time evolution of fluorescence and absorption spectra of camptothecins
Author Affiliations +
Proceedings Volume 5566, Optical Security and Safety; (2004) https://doi.org/10.1117/12.577162
Event: Optical Security and Safety, 2003, Warsaw, Poland
Camptothecins, fluorescent anticancer agents, exhibit at neutral and physiological pH changes over time in absorption and fluorescence spectra. Analysis of these changes is a subject of this paper. Factor analysis of fluorescence spectra enabled to determine the kinetics of hydrolysis of camptothecin, i.e. the rate of converting of biologically active lactone form into inactive carboxylate. Obtained results are compared with HPLC data.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Blanka Ziomkowska, Blanka Ziomkowska, Stefan Kruszewski, Stefan Kruszewski, Ryszard Siuda, Ryszard Siuda, Michal Cyrankiewicz, Michal Cyrankiewicz, } "Analysis of time evolution of fluorescence and absorption spectra of camptothecins", Proc. SPIE 5566, Optical Security and Safety, (26 August 2004); doi: 10.1117/12.577162; https://doi.org/10.1117/12.577162

Back to Top