The Special Ordered Structures of Specialty Fiber included into Multifunctional and Multi Channel Fiber Optic Bundles (MFOB) and Sensors are proposed. Optimal construction of fiber optic channels in the MFOB exhibit reduced speckle noise and high intensity transmission resulting from spatial homogeneity and symmetry of radiation. Improved new type of the Fibers: Metal Coated Multimode, Special Plastic Coated, Fibers for UV-VIS, Fibers for VIS-NIR spectral Range, Fibers for NIR and IR spectral range. Hexagonal package of sensitive end of the MFOB structures designed with different type and fiber core diameters fibers are transferred into the different configured input/output optical channels. For fluorescence spectroscopy and FDT Diagnostic described optimal arrangement with 7-256 Fibers included into MFOB structure. Remote spectroscopic Probes are used for "in Vivo" or "in Vitro" experimental devices. Sensors with MFOB probes bifurcated from two up to seven channels are used for process photometry and for mini-fiber spectrometric devices. Customized Software and flexible numerical simulations for data analysis are based into two levels of programming: -micro program part for ATMEL microprocessor, Visual C++ version 6.0 for PC computers with Windows -98-2000Me Programs. Advanced Applications of MFOB type of probes show some features for Biomedical Remote Sensing Systems: High Optical Throughput for Special Fluorescence Probes; High Stability for fool spectral range; Minimal cross link between fibers into MFOB-M structures; High stability for Endoscopes and sterilization proof tested solutions; Quality Controlled Scattered Reflection MFOB. MFOB structures designed with Mini Fiber Spectrometers show high spectral resolution (7 - 12 nm) and possibility to combine in one set different function: Normalization function for different light sources, Multi scan measurements with adjusted time duration, Spectral band analysis (including integrated characters for selected wavebands), Fast time resolution for selected types of scanning characters.