9 December 2004 MOEMS-based cardiac enzymes detector for acute myocardial infarction
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Abstract
Biomedical applications of MOEMS are limited only by the humankind imagination. Precision measurements are minute amounts of biological material could be performed by optical means with a remarkable accuracy. Although available in medical laboratories, such analyzers are making their way directly to the users. Such an example is the test kit to detect the existence of cardiac enzymes in the blood stream. Apart from the direct users, the medical personnel will make use of such tools given the practicality of the kit. In a large proportion of patients admitted to hospital suspected of Acute Myocardial Infarction (AMI), the symptoms and electrocardiographic changes are inconclusive. This necessitates the use of biochemical markers of myocardial damage for correct exclusion or conformation of AMI. New cardiac-specific markers have recently been introduced into the detection of AMI. The cardiac troponins, because of their extraordinary high specificity for myocardial cell injury, have gained particular interest. Experimental setup involves the use of a rectangle shaped AFM cantilevers, optical lenses, laser source, oscilloscope and a charged coupled device (CCD) to detect the cantilever deflection. When specific biomolecular binding occurs on one surface of a microcantilever beam, intermolecular nanomechanics bend the cantilever, which can be detected optically. Based upon the above concept, troponin I was detected optically by depositing it on the microcantilever containing anti-troponin I. The laser beam was directed on the cantilever and the deflection noted on the CCD.
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Jeetender Amritsar, Ion G. Stiharu, Muthukumaran Packirisamy, Ganesharam Balagopal, Xing Li, "MOEMS-based cardiac enzymes detector for acute myocardial infarction", Proc. SPIE 5578, Photonics North 2004: Photonic Applications in Astronomy, Biomedicine, Imaging, Materials Processing, and Education, (9 December 2004); doi: 10.1117/12.567678; https://doi.org/10.1117/12.567678
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