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8 December 2004 Separation of blood cells and plasma in microchannel bend structures
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Proceedings Volume 5591, Lab-on-a-Chip: Platforms, Devices, and Applications; (2004) https://doi.org/10.1117/12.568823
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States
Abstract
Biological applications of micro assay devices require easy implementable on-chip microfluidics for separation of plasma or serum from blood. This is achieved by a new blood separation technique based on a microchannel bend structure developed within the collaborative Micro-Tele-BioChip (μTBC) project. Different prototype polymer chips have been manufactured with an UV-LIGA process and hot embossing technology. The separation mechanisms have been identified and the separation efficiency of these chips has been determined by experimental measurements using human blood samples. Results show different separation efficiencies for cells and plasma up to 100 % depending on microchannel geometry, hematocrit, and feed velocity. This novel technique leads to an alternative blood separation method as compared to existing micro separation technologies.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Christoph Blattert, Reinhold Jurischka, Andreas Schoth, Paul Kerth, and Wolfgang Menz "Separation of blood cells and plasma in microchannel bend structures", Proc. SPIE 5591, Lab-on-a-Chip: Platforms, Devices, and Applications, (8 December 2004); https://doi.org/10.1117/12.568823
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