I will review recent advances in DoD nanoscience and technology (NST) at the Air Force Research Laboratory (AFRL) in the areas of nano-materials, nano-electronics, and nano-energetics. NST will profoundly change all critical aspects of maintaining a technologically superior national defense capability. In this talk, I will focus on programmatic priorities for AFRL basic and applied R&D in the seven selected priority areas that comprise the AFRL Strategic Nanotech Plan. The goal of this plan is to focus, prioritize and guide future AF funding in nanotechnology. The selected topics include: tailorable dielectrics, reconfigurable optical response materials, adaptive structural materials, quantum confined optical sensors and sources, nanotechnology for RF, as well as several cross-cutting topics such as self-assembly, interfaces, and modeling and simulation.