Cytotoxicity of the photoproducts of Photogem after photobleaching induced by intense illumination

Priscila F.C. Menezes; Hidetake Imasato; Janice R. Perussi; Claudia Adriana Sousa Melo; Vanderlei Salvador Bagnato

doi:10.1117/12.589417

21 October 2004 Cytotoxicity of the photoproducts of Photogem after photobleaching induced by intense illumination

Priscila F.C. Menezes, Hidetake Imasato, Janice R. Perussi, Claudia Adriana Sousa Melo, Vanderlei Salvador Bagnato

Proceedings Volume 5622, 5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications; (2004) https://doi.org/10.1117/12.589417
Event: 5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications, 2004, Porlamar, Venezuela

Abstract

Porphyrins can be degraded by light. Photogem is a photosensitizer used in PDT in Brazil. Photogem irradiation at 514 and 630 nm change its fluorescence and absorption due to photodegradation and photoproducts formation (new absorption band in 640 nm). Irradiated Photogem was incubated with tumor or non-tumor cells. The low toxicity suggests that the photoproducts of Photogem are less cytotoxic than the original formulation.

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Priscila F.C. Menezes, Hidetake Imasato, Janice R. Perussi, Claudia Adriana Sousa Melo, and Vanderlei Salvador Bagnato "Cytotoxicity of the photoproducts of Photogem after photobleaching induced by intense illumination", Proc. SPIE 5622, 5th Iberoamerican Meeting on Optics and 8th Latin American Meeting on Optics, Lasers, and Their Applications, (21 October 2004); https://doi.org/10.1117/12.589417

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