Photobiomodulation: phenomenology and its mechanism

Timon Cheng-Yi Liu; Jian-Ling Jiao; Xiao-Yang Xu; Xiao-Guang Liu; Shu-Xun Deng; Song-Hao Liu

doi:10.1117/12.581165

18 January 2005 Photobiomodulation: phenomenology and its mechanism

Timon Cheng-Yi Liu, Jian-Ling Jiao, Xiao-Yang Xu, Xiao-Guang Liu, Shu-Xun Deng, Song-Hao Liu

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.581165
Event: Photonics Asia, 2004, Beijing, China

Abstract

There are two kinds of pathways mediating cellular photobiomodulation, the specific one is mediated by the resonant interaction of light with molecules such as cytochrome nitrosyl complexes of mitochondrial electron transfer chain, singlet oxygen, hemoglobin or photosensentor such as endogenous porphyrines, the non-specific one is mediated by the non-resonant interaction of light with membrane proteins. Some of specific pathways mediating photobiomodulation can damage membrane or cell compartments such as mitochondria, lysosomes, endoplasmic reticulum by photodynamic damage if the light intensity is very high so that photodynamic damage will limit the maximum intensity of the light of photobiomodulation although the non-specific pathways mediating photobiomodulation might not damage cells. As the reciprocity law, the rule of Bunsen and Roscoe, was not obeyed for almost all the studied photobiomodulation, and the light energy reaps the greatest benefit where it is most needed, photobiomodulation was thought to be dominantly mediated by the non-specific pathways although the specific pathways can act as a role, which is supported by the dose relationship research in which the photobiomodulation effects were found to be the SIN function of radiation time in many works on the dose relationship when the intensity is kept constant. The non-specific pathways were mainly mediated by membrane receptors and the ultraweak non-resonant interaction of light with membrane receptors can be physically amplified by the coherent state of membrane receptors and then chemically exemplified by signal transduction according to our biological information model of photobiomodulation supported by its successful cellular, animal and clinic applications.

Citation Download Citation

Timon Cheng-Yi Liu, Jian-Ling Jiao, Xiao-Yang Xu, Xiao-Guang Liu, Shu-Xun Deng, and Song-Hao Liu "Photobiomodulation: phenomenology and its mechanism", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.581165

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