18 January 2005 Physical analysis on laser-induced cerebral damage
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Experimental investigation on cerebral damage of adult SD rats induced by 532nm CW laser was performed. Tissue heat conductive equation was set up based on two-layered structure model. Finite difference algorithm was utilized to numerically simulate the temperature distribution in the brain tissue. Allowing for tissue response to temperature variation, free boundary model was used to discuss tissue thermal coagulation formation in brain. Experimental observations show that thermal coagulation and necrosis can be caused due to laser light absorption. The result of the calculation shows that the process of the thermal coagulation of the given mode comprises two stages: fast and slow. At the first stage, necrosis domain grows fast. Then necrosis domain growth becomes slower because of the competition between the heat diffusion into the surrounding undamaged tissue and the heat dissipation caused by blood perfusion. At the center of coagulation area no neuron was observed and at the transitional zone few nervous cells were seen by microscope. The research can provide reference data for developing clinical therapy of some kind of encephalic diseases by using 532nm laser, and for making cerebral infarction models in animal experiment.
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Xiaosen Luo, Xiaosen Luo, Jiangang Liu, Jiangang Liu, Chunkan Tao, Chunkan Tao, Xiufeng Lan, Xiufeng Lan, Lingyan Cao, Lingyan Cao, Weimin Pan, Weimin Pan, Zhonghua Shen, Zhonghua Shen, Jian Lu, Jian Lu, Xiaowu Ni, Xiaowu Ni, "Physical analysis on laser-induced cerebral damage", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.575507; https://doi.org/10.1117/12.575507

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