16 February 2005 All-fiber optic endoscope probe distal end for disease diagnosis in body cavities
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Abstract
In this paper, we present the design of an endoscope probe, which can image the inner cavity walls as well as collect fluorescence emission from the same cavity inner surfaces, for disease diagnosis in body cavities. The probe makes use of a single coherent laser illumination / excitation source for both modalities. An imaging lens at the probe end collects the fluorescence emission as well as the image from the test surface. Two types of imaging lens are used in the probe and their fluorescence collection efficiencies and imaging capabilities are compared with each other. An eyepiece at the end of the probe directs the transmitted light into a CCD camera / Monochromator through selected filters to display the image / analyze the emission spectrum. The developed probe has been tested in a phantom colon model, where cancerous growths and fluorophores are simulated, so as to illustrate the probe diagnostic efficiency.
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Vadakke Matham Murukeshan, N. Sujatha, Leong Keey Seah, Lin Seng Ong, "All-fiber optic endoscope probe distal end for disease diagnosis in body cavities", Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); doi: 10.1117/12.580468; https://doi.org/10.1117/12.580468
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