Bicontinuous thermoresponsive L<sub>3</sub>-phase silica nanocomposites and their smart drug delivery applications

Jeong Ho Chang; Kyung Ja Kim

doi:10.1117/12.581038

16 February 2005 Bicontinuous thermoresponsive L₃-phase silica nanocomposites and their smart drug delivery applications

Jeong Ho Chang, Kyung Ja Kim

Author Affiliations +

Proceedings Volume 5651, Biomedical Applications of Micro- and Nanoengineering II; (2005) https://doi.org/10.1117/12.581038
Event: Smart Materials, Nano-, and Micro-Smart Systems, 2004, Sydney, Australia

Abstract

This work describes an innovative approach to preparation of the highly controlled drug delivery materials that involves a self-assembly process at the molecular level based upon the silicified L₃ phase silicates and thermoresponsive PNIPAm integrated L₃ phase silicates. The materials designed by the integration of thermosensitive polymer have been prepared and demonstrated for the highly controlled drug releasing system over a longer period of time due to their high degree of continuity and contigunity in 3-D interconnected porous structure. This approach is suitable for long term drug delivery systems with constant release in hard tissue engineering due to nanodiffusion mechanism. The structural characterization was achieved by TEM, SEM, SAXD, solid-state ²⁹Si NMR, and BET.

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Jeong Ho Chang and Kyung Ja Kim "Bicontinuous thermoresponsive L₃-phase silica nanocomposites and their smart drug delivery applications", Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); https://doi.org/10.1117/12.581038

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