Biomimetic application of tailored mesoporous materials with self-assembled multifunctional monolayers

Jeong Ho Chang; Kyung Ja Kim

doi:10.1117/12.581163

16 February 2005 Biomimetic application of tailored mesoporous materials with self-assembled multifunctional monolayers

Jeong Ho Chang, Kyung Ja Kim

Proceedings Volume 5651, Biomedical Applications of Micro- and Nanoengineering II; (2005) https://doi.org/10.1117/12.581163
Event: Smart Materials, Nano-, and Micro-Smart Systems, 2004, Sydney, Australia

Abstract

This paper describes chemically functionalized mesoporous silica as a novel catalyst for the rapid hydrolysis of a phenyl ester. Work demonstrates a very simple and flexible approach to control surface reactivity on the nanometer scale using a self-assembled organic monolayer consisting of polar, (dihydroxyl, carboxyl, ethylene-diamine, and dihydroimidazole), and non-polar (isobutyl) groups. All five functional groups are an essential requirement in preparing an enzyme-like catalyst because of the synergistic effect and hydrophobic partitioning, which has been verified by a 13C CP- MAS solid-state NMR technique. Catalytic activities were obtained from the catalytic efficiency constant and specificity constant using Michaelis-Menten kinetics. Catalytic activities were close to those of a natural enzyme when 12% of the surface was covered by hydrophobic isobutyl silane. The rate of enzyme catalyzed activity was dependent on the energy of the transition state as defined in terms of an energy barrier derived from the relationship between transfer free energy and specificity constant.

Citation Download Citation

Jeong Ho Chang and Kyung Ja Kim "Biomimetic application of tailored mesoporous materials with self-assembled multifunctional monolayers", Proc. SPIE 5651, Biomedical Applications of Micro- and Nanoengineering II, (16 February 2005); https://doi.org/10.1117/12.581163

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